Anna, Molly, Ming, Caroline, Helen: the Old Friends. Since adopting their official name aged 11, they have seen each other through careers, children, illnesses, marriage, divorce, addiction, fame, fall outs. But now, Anna - fiercely loved mother and friend, and the Old Friends' glue - is diagnosed with cancer again, and this time, tired of recoveries and relapses, pitying looks and exhausting regimes, she simply says: no more. As her health declines, the politics of the still lived-in world merge with memories of the past while each Old Friend tries to accept the truth of what is happening: they are losing someone they cannot imagine life without. Some will fight her decision, some will accept it, but all will rejoice in a life fully lived.