Enola Holmes is on the run from the world's most famous detective - her brother Sherlock Holmes. As she roams the dark and dangerous streets of London disguised as a doctor's secretary called Miss Ivy Meshle, Enola is reminded more and more that her name backwards spells 'alone'. But when she finds a concealed cache of dazzling charcoal drawings, she feels drawn to the girl who drew them. Only, that girl, young Lady Cecily, has mysteriously vanished. It's up to Enola to find her, but false appearances can only last so long.