Mary is the great-niece of Victor Frankenstein. She knows her uncle disappeared in mysterious circumstances in the Arctic but she doesn't know why or how. She and her husband are trying to make a name for themselves as paleontologists but, in 1850s' London, scientific success requires wealth and connections - neither of which they possess. But then Mary discovers some old family papers that allude to the truth behind her great-uncle's past, of his attempts to create a living being and the creature that ultimately killed him. Perhaps this idea will prove to be their salvation.